Guidelines for pregnancies up to 12 weeks:

Step 1: Insert four 200-mcg tablets (or their equivalent) deeply into the vagina or in the mouth under the tongue or in the cheek pouch.  If tablets are placed under the tongue or in the cheek pouch, hold in the mouth for 20-30 minutes to allow them to dissolve, and then swallow the remaining fragments.Bleeding and uterine contractions(cramping) may begin half an hour following this first step and will almost always start within the first 12 hours.  Bleeding itself does not mean that an abortion has occurred.  Close inspection of the sanitary pad or other receptacle may reveal whether the pregnancy has been terminated.This will be difficult to detect in very early stages of pregnancy, however, because the embryonic tissue is indistinguishable from the normal clotting of menstrual blood.

Step 2: If tablets were administered vaginally in Step 1, insert four more 200-mcg tablets of misoprostol deep into the vagina three to 12 hours after the first administration.If tablets were administered by mouth in Step 1, place four more 200-mcg tablets under the tongue or in the cheek pouch three hours after the first administration and hold them there for 20-30 minutes until they dissolve.  The shorter time interval between steps for tablets in the mouth is needed to achieve the same effectiveness  as vaginal administration at longer intervals but may cause more side effects. 

                       Step 3: If the pregnancy has not been terminated after using the second set of pills and bleeding, insert four more 200mcg tablets of misoprostol 3 to 12 hours after the second vagina administration or three hours after the second administration by mouth. The majority pregnancies up to 12 weeks duration are terminated within hours of the first administration of misoprostol.  Generally, more than three quarters of women experience abortion within the first 24 hours, although it sometimes takes longer.